Aviation has an exemption to use Halon fire extinguishers which are extremely effective in the aviation environment.
Oxygen masks would be used after it has been discharged in the flight deck.
You would try to keep oxy away from a naked flame obviously, but if the masks need to be used, then you'd use them.
For a fire in the cabin, you would remove any nearby oxy bottles to ensure you don't flame the fire.
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